Astrogation can cancel when trying to enter autopilt vector by hand
https://discord.com/channels/426287934870781952/1101390142620569651/1101390142620569651
This happens when using autopilot controls (RMB) and manual (SHIFT) concurrently. RMB can cause your autopilot vector to adapt to minute changes in the velocities and end up in an opposite-to-astrogation position.
Edited by Mariusz Chwalba